Description
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WHAT It means.
3-Methoxyphencyclidine (3-meO-pcp) is a dissociative hallucinogen of the arylcyclohexylamine class related to phencyclidine (PCP)
which has been sold online as a designer drug.It acts mainly as an NMDA receptor antagonist, though it has also been found to interact with the sigma σ1 receptor and the serotonin transporter.The drug does not possess any opioid activity nor does it act as a dopamine reuptake inhibitor.buy 3-MeO-PCP OHIO
Pharmacology.buy 3-MeO-PCP
3-MeO-PCP has a Ki of 20 nM for the dizocilpine (MK-801) site of the NMDA receptor, 216 nM for the serotonin transporter (SERT), and 42 nM for the sigma σ1 receptor.[3][2] It does not bind to the norepinephrine or dopamine transporter nor to the sigma σ2 receptor (Ki >10,000 nM).buy 3-MeO-PCP OHIO.Based on its structural similarity to 3-hydroxy-PCP (3-HO-PCP), which uniquely among arylcyclohexylamines has high affinity for the μ-opioid receptor in addition to the NMDA receptor, it was initially expected that 3-MeO-PCP would have opioid activity. However, radioligand binding assays with human proteins have shown that, contrary to common belief, the drug also does not interact with the μ-, δ-, or κ-opioid receptors at concentrations of up to 10,000 nM.As such, the notion that 3-meo-PCP has opioid activity has been described as a myth.buy 3-MeO-PCP OHIO
3-MeO-PCP binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions of PCP, followed by 2-MeO-PCP and 4-MeO-PCP.buy 3-MeO-PCP OHIO
Chemistry.
3-MeO-PCP hydrochloride is solid with a melting point of 204–205 °C.buy 3-MeO-PCP OHIO
History
3-MeO-PCP was first synthesized in 1979 to investigate the structure–activity relationships of phencyclidine (PCP) derivatives. The effects of 3-meo-pcp in humans were not described until 1999 when a chemist using the pseudonym John Q. Beagle wrote that 3-MeO-PCP was qualitatively similar to PCP with comparable potency.3-MeO-PCP was preceded by the less potent dissociative 4-MeO-PCP and first became available as a research chemical in 2011.buy 3-meo-pcp OHIO
Subjective effects
3-MeO-PCP is commonly described as being more stimulating and less immobilizing than other dissociatives such as ketamine or MXE.
At lower doses, it can induce sensory enhancements such as color enhancement, acuity enhancement, tactile enhancement, auditory enhancement and bodily control enhancement. At medium to high doses it presents sensory suppressions such as tactile suppression, motor control loss, auditory suppression and acuity suppression.
Based on a large amount of experience reports, it appears to be considerably more likely to induce mania, delusions, and psychosis than other dissociatives (possibly due to its unusually high potency, compulsivity and erratic dose response.buy 3-MeO-PCP OHIO
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death
